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| First Name: | Hui | | Last Name: | Zheng | | Title: | Director, Huffington Center on Aging Professor, Departments of Molecular and Human Genetics | | Advanced Degrees: | Ph.D. | | Affiliation: | Baylor College of Medicine | | Department: | Molecular and Cellular Biology and Neuroscience | | Street Address 1: | One Baylor Plaza, M320 | | City: | Houston | | State/Province: | TX | | Zip/Postal Code: | 77030 | Country/Territory: | U.S.A. | | Phone: | 713-798-1568 | | Fax: | 713-798-1610 | | Email Address: |  |
Disclosure:
(view policy)
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View all comments by Hui Zheng
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Aging Process, Neurodevelopmental Disorders (Down syndrome, etc.), Alzheimer Disease
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Apoptosis/Cell cycle, Brain imaging, Signal transduction, Electrophysiology, Stem cells, Genetics, A-beta PP/A-beta, Animal Models, Molecular and Cell biology, Neurobiology, Oxidative Stress
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EDUCATION
B.S., Chemistry, Peking University, Beijing, China. 1984
Ph.D., Biochemistry, Baylor College of Medicine, Houston, Texas. 1990. Mentor: John H. Wilson, Ph.D.
RESEARCH AND PROFESSIONAL EXPERIENCE
Postdoctoral fellow, Genetics. Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, 1990-1991. Mentor: Allan Bradley, Ph.D.
Senior Research Biologist, Merck Research Laboratories, Rahway, New Jersey, 1991-1995.
Research Fellow, Merck Research Laboratories, Rahway, New Jersey, 1995-1999.
Assistant Professor, Huffington Center on Aging and Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, 1999-present.
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1. Zheng, H. and Wilson, J.H. (1990) Gene targeting in normal and amplified cell lines. Nature. 344: 170-173.
2. Zheng, H., Jiang, M., Trumbauer, M., Sirinathsinghji, D., Hopkins, R., Smith, D., Heavens, R., Dawson, G., Boyce, S., Conner, M., Stevens, K., Slunt, H., Sisodia, S.S., Chen, H. and Van der Ploeg, L. (1995). beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81: 525-531.
3. Zheng, H., Fletcher, D., Kozak, W., Jiang, M., Hofmann, K., Conn, C., Soszynski, D., Grabiec, C., Trumbauer, M., Shaw, A., Kostura, M., Stevens, K., Rosen, H., North, R.J., Chen, H., Tocci, M.J., Kluger, M. & Van der Ploeg, L. (1995). Resistance to fever induction and impaired acute-phase response in interleukin-1ƒÒ deficient mice. Immunity 3: 9-19.
4. Wong, P.*, Zheng, H.*, Chen, H., Becher, M.W., Sirianthsinghji, D.J.S., Trumbauer, M.E., Chen, H.Y., Price, D.L., Van der Ploeg, L.H.T. and Sisodia, S.S. (1997). Presenilin 1 is required for Notch 1 and Dll 1 expression in the paraxial mesoderm. Nature 387: 288-292. *equal contribution.
5. Qian, S., Jiang, P., Guan, X., Singh, G., Trumbauer, M.E., Hong, Y., Chen, H.Y., Van der Ploeg, L.H.T. and Zheng, H. (1998). Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates AƒÒ1ƒ{42/43 expression. Neuron 20: 611-617.
6. Xia, X., Qian, S., Soriano, S., Wu, Y., Fletcher, A., Wang, X.-J., Koo, E.H., Wu, X., and Zheng, H. (2001). Loss of presenilin 1 is associated with enhanced ƒÒ-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. USA. 98: 10863-10868.
7. Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., and Striessnig, J. (2000). Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell, 102: 89-97.
8. Soriano, S., Kang, D.E., Fu, M., Chevallier, N., Pestell, R., Zheng, H., and Koo, E.H. (2001). Presenilin 1 negatively regulates beta-catenin/T cell Factor/Lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and Notch processing. J. Cell Biol., 152: 785-794.
9. Dineley, K.T., Xia, X., Bui, D., Sweatt, J.D., and Zheng, H. (2002). Accelerated plaque accumulation, associative learning deficits and up-regulation of Ą7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem., 277: 22768-22780.
10. Xia, X., Wang, P., Sun, X., Soriano, S., Shum, W.-K., Trumbauer, M.E., Takashima, A., Koo, E.H., and Zheng, H. (2002). The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin independent mechanisms. Proc. Natl. Acad. Sci. USA, 99: 8760-8765.
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